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Aalto has multifaceted expertise and several active work groups in the area relating to design and premises. 

The Department of Architecture comprises study programs in architecture, landscape architecture, and interior architecture. The , which has been active since the 1980s, specializes in research on social and healthcare buildings and urban viability and health. Health and wellbeing topic areas have included design and new directions of hospitals and acute care, community health centers, end of life care facilities, and all levels of supported housing, as well as complex residential care. A recent consortium project explored integrated housing solutions for persons undergoing memory decline. Additional aspects of health and wellbeing and human centered design include, for example, sensory design, service design, universal design, therapeutic landscapes, and urban health. Health and wellbeing architecture takes focus not only on static matters, but also on how buildings function.

A professorial group in indoor air quality and interior environment has a span of expertise from the initial stages of design all the way through construction completion and subsequent maintenance. Indoor air quality research is conducted in an interdisciplinary research group, and the goal of the research is to ensure a healthy, safe, and comfortable indoor environment in buildings. Knowledge provided by research enables the prevention, identification, and correction of possible problems and hazards related to indoor air quality, as well as developing methods to ensure good indoor air quality.